BACTERIAL CELL CYCLE AND PRECISION CONTROL IN BIOLOGY

Balanced biosynthesis is a fundamental aspect of bacterial cell physiology, ensuring stable protein concentrations within the cell. However, this poses a conceptual challenge for modeling the cell cycle and cell-size controls in bacteria, as prevailing concentration-based eukaryote models are not directly applicable. In this talk, I will explain how bacteria precisely and robustly control replication initiation through protein copy-number sensing and discuss its general implications in quantitative biology.