Membrane proteins are central to life and their correct biogenesis is critical to cellular homeostasis. In recent years, our group has focused on the targeting of tail-anchored membrane (TA) proteins to the ER by the GET pathway. For this system, a TA-protein first binds to the co-chaperone Sgt2 that delivers this cargo to the Get3 ATPase via a bridging Get4/Get5 complex. Get3 then delivers the TA cargo to receptors on the ER. The talk will begin focused on the canonical pathway found in yeast and mammals. Next, recent work from studies of a protist Get3 will be presented that highlight the detailed conformational changes of Get3 during the ATPase cycle. The final topic will cover unpublished work on a plant Get3 homolog that has evolutionary implication for the biogenesis of the photosynthetic machinery.