Structural Biology of Bacterial cell-wall remodeling: Implications in Antimicrobial Resistance

Body: 

The bacterial cell wall is an elastic gigantic macromolecule that defines the shape of the bacterium and enables the bacterium to resist lysis as a result of its high intracellular osmotic pressure. How bacteria grow and divide while retaining a defined shape is a fundamental question in microbiology. The critical processes of cell growth and division require cell-wall remodeling by different enzymatic machineries that are carefully coordinated/regulated in order to warrant bacterial survival. In this talk some recent results on the structural biology of cell wall remodeling processes in very important multidrug-resistant pathogens such as Pseudomonas aeruginosa or MRSA will be presented.

Host: 
Jose Martin Garcia
Affiliation: 
Consejo Superior de Investigaciones Cientificas (CSIC), Madrid, Spain
Speaker: 
Juan Hermoso
Date: 
Wednesday, April 3, 2019
Year: 
2019
Semester: 
Spring