The bacterial cell wall is an elastic gigantic macromolecule that defines the shape of the bacterium and enables the bacterium to resist lysis as a result of its high intracellular osmotic pressure. How bacteria grow and divide while retaining a defined shape is a fundamental question in microbiology. The critical processes of cell growth and division require cell-wall remodeling by different enzymatic machineries that are carefully coordinated/regulated in order to warrant bacterial survival. In this talk some recent results on the structural biology of cell wall remodeling processes in very important multidrug-resistant pathogens such as Pseudomonas aeruginosa or MRSA will be presented.
Jose Martin Garcia
Consejo Superior de Investigaciones Cientificas (CSIC), Madrid, Spain
Wednesday, April 3, 2019